有什么问题吗的英语表达可以是：What is your problem？或者用疑问语气的Any problem？就可以表达。表示对他人的问候时可以说：Whats the matter with you?
例句示范
What is your problem? Im your boss.
你怎么回事？我是你老板。
What is your problem anyway?
总之，你到底有什么问题？
You know? Im focused! What is your problem?
你知道吗？我应该被关注的！而你呢？
What is your problem with him anyways?
总之你对他还有什么意见呢？
Then what is your problem?
那你有什么难题？
Will that bother you? What is your problem with footballers?
那会使你感到厌烦么？足球运动员有什么不妥？
What is your problem in studying English?
学英语，你的问题在哪儿？
You are acting strangely. Whats the matter with you?
你最近怎么行为怪异，出什么事了吗？
Whats the matter with you? You haven done enough hero work for one day?
你到底怎么了？你当英雄还不够么？
Whats the matter with you? Are you looking to get run over?
你怎么搞的？你想被辗过吗？
Hes coming back this morning. whats the matter with you?
他今天上午来，你到底是怎么回事？
Whats the matter with you, walking along with a long face?
你怎么啦，拉长了脸四处走。
