端粒酶抑制剂,telomerase inhibitor
1)telomerase inhibitor端粒酶抑制剂
1.Effects of intratumoral injection oftelomerase inhibitor AZT on implanted liver cancer in rats;瘤内注射端粒酶抑制剂AZT对大鼠种植性肝癌的影响
2.Construction and transformation of fusion expression protein used in high throughput screening model fortelomerase inhibitors高通量端粒酶抑制剂筛选模型融合表达载体的构建及转化
3.The purpose of this study was to evaluate the effect oftelomerase inhibitors combined with X irradiation on bone marrow hematopoiesis in tumor carrying mice.为了探讨端粒酶抑制剂联合X线照射对荷瘤小鼠的骨髓抑制作用 ,采用正交实验设计 ,应用端粒酶抑制剂 [AZT 30 0mg/ (kg·d) ,lamivudine 15 0mg/ (kg·d) ]联合X线照射 (2Gy× 5次 / 1周 )处理移植性乳腺癌 (MA782 )小鼠 ,观察其对骨髓有核细胞、外周血像及骨髓端粒酶活性的影响。
英文短句/例句
1.Construction of Screening Model for Telomerase Inhibitors Contained Human Telomerase RNA Mutant含人端粒酶RNA突变体的端粒酶抑制剂筛选模型的构建
2.The Research of Telomerase Inhibitors on Human Hepatocelluar Carcinoma Cells and Nasopharyngeal Carcinoma Cells;端粒酶抑制剂对肝癌、鼻咽癌细胞株作用的研究
3.Studies on a Series of Porphyrin Complexes Targeting G-Quadruplex DNA以G4-DNA为靶点的卟啉类端粒酶抑制剂的研究
4.Construction and transformation of bait fusion vector used in high throughput screening assay model for telomerase inhibitors端粒酶抑制剂筛选模型诱饵载体的构建与转化
5.The Effect of Telomerase Inhibitors to Ovarian Cancer Cell Strains with Different Sensitivity to Cisplatin;端粒酶抑制剂对顺铂不同敏感性卵巢癌细胞株的影响
6.Studies on the Synthesis, Characterization and Antitumor Activity of a Series of Novel Ruthenium(II) Porphyrin Complexes Targeted to G-Quadruplex DNA;以G-四链体为靶点的端粒酶抑制剂的合成及其活性研究
7.A Yeast 3-hybrid System for High-throughput Screening of the Human Telomerase Inhibition基于酵母三杂交系统端粒酶抑制剂高通量筛选模型的建立
8.Construction and transformation of fusion expression protein used in high throughput screening model for telomerase inhibitors高通量端粒酶抑制剂筛选模型融合表达载体的构建及转化
9.Changes of Gene Expression Profiles in Human Hepatocelluar Cancer Cell Line SMMC-7721 and Human Nasopharyngeal Carcinoma Cell Line CNE2 by Telomerase Inhibitors;端粒酶抑制剂作用人肝癌、鼻咽癌细胞株前后基因表达谱和蛋白表达谱变化的研究
10.To design HDV ribozyme for human telomerase RNA( hTR) component, and observe its inhibition for telomerase activity. Pseudoknotted g.设计针对端粒酶的HDV核酶,观察其对端粒酶活性抑制。
11.Inhibition of Telomerase Activity by siRNA Targeted to Human Telomerase Reverse Transcriptase;人端粒酶反转录酶siRNA抑制肿瘤细胞端粒酶活性的研究
12.PinX1 may repress telomerase activity by Mad1/c-Myc pathwayPinX1可通过Mad1/c-Myc途径抑制端粒酶活性
13.The Human Pif1 Encodes a RecD-like Helicase That Regulates Telomere Elongation Through Inhibition of Telomerase Activity;人的类RecD解旋酶Pif1通过抑制端粒酶活性调控端粒延伸
14.Inhibition Effects of RNAi on Telomerase Activation in ECA109 Cells;RNAi抑制食管癌细胞系ECA109端粒酶活性的实验研究
15.A Research about the Relation of Inhibiting Telomerase Activity and Cervical Cancer Cells Proliferation;抑制端粒酶活性与宫颈癌细胞增殖关系的研究
16.Inhibiting Telomerase Activity of Liver Cancer Cell Line SMMC-7721 by Antisense hTRT;反义hTRT对人肝癌细胞株SMMC-7721端粒酶的抑制作用
17.Inhibition Effects of RNAi on Telomerase Activition in the Colon Carcinoma Cell Line HT-29;RNAi抑制结肠癌细胞系HT-29端粒酶活性的研究
18.Effective Inhibition of Telomerase Activity in Breast Cancer Cell T47D by siRNA;小干扰RNA抑制乳腺癌T47D细胞端粒酶活性的研究
相关短句/例句
Telomerase inhibitors端粒酶抑制剂
1.Telomerase and telomerase inhibitors;端粒酶和端粒酶抑制剂(英文)
3)telomerase inhibition端粒酶抑制
4)telomrase inhibiting activity端粒酶抑制活性
5)enzyme inhibitor酶抑制剂
1.Advance in the antiviralenzyme inhibitors;酶抑制剂类抗病毒药物的研究进展
2.The ability of microorganisms (Nocardia, Mycobacterium and Arthrobacter) is studied to degrade the soybean sterol, the influence ofenzyme inhibitors, which inclus Ni2+.测定了诺卡氏菌（Ｎｏｃａｒｄｉａ）、分枝杆菌（Ｍｙｃｏｂ ａｃｔｅｒｉｕｍ）和节杆菌（Ａｒｔｈｒｏｂ ａｃｔｅｒ）对大豆甾醇的降解能力及Ｎｉ２＋，Ｃｏ２＋，Ｍｎ２＋，α、α’－联吡啶、邻菲罗琳等酶抑制剂对△１，４－雄甾二烯－３， １７－二酮（ＡＤＤ）积累的影响。
3.OBJECTIVE: To screen and isolate the cholesterol biosyntheticenzyme inhibitors from SIPI 17.目的：筛选和分离微生物产生的胆固醇生物合成酶抑制剂。
6)inhibitor[英][in"hibit?][美][?n"h?b?t?]酶抑制剂
1.When immobilized PLA1,inhibitor can couple amine residues which are important for catalysis or maintaining proteinstructure.在固定化磷脂酶A1时,利用酶抑制剂与磷脂酶A1活性中心氨基酸残基结合,使戊二醛基与磷脂酶A1的非活性氨基残基缩合,从而起到保护酶活性中心基团,提高固定化酶活力作用。
2.Peptidaseinhibitor(Bestatin and Amastin)was used;20mmol/L Gly-Gly and Gly-L-Leu as control,and each kind s dipeptide solution was treated withinhibitor as test group.2种二肽培养液(Gly-Gly肽和Gly-L-Leu肽溶液)作为两组对照培养液,每种二肽培养液中添加肽酶抑制剂(Bestatin和Amastatin),作为试验培养液,39。
延伸阅读
端粒酶分子式：CAS号：性质：一种以逆转录的方式合成真核细胞中线性染色体端粒DNA的特殊酶。该酶的辅基为一特定的RNA，端粒DNA的合成必须依赖酶分子中的辅基RNA为模板，通过逆转录而完成，其自身携带RNA作为产物的模板是区别于一般由纯蛋白组成的逆转录DNA聚合酶的主要特征。在逆转录时需要一个DNA引物，以便从5′→3′方向添加端粒的重复序列。底物是脱氧核苷三磷酸(dNTPs)。如在四膜虫(tetraphymena)中，四膜虫端粒酶催化反应式如下：染色体-GGGGTTGGGGTT(DNA引物)+4ndGTP(dNTPs)+2nTTP(dNTPs)→染色体-GGGGTTGGGGTT(GGGGTT)n(四膜虫端粒DNA)+6n焦磷酸端粒酶的活性在胚系细胞、癌化细胞中活跃；在体细胞，尤其经多次分裂后的体细胞，其活性降低。该酶的活性也可能是多细胞器官限制其细胞增殖的一种机制之一。
