关注“奥维抗病营养”
掌握更多专业知识和市场行情
文Id献
原名:Neonatal Vitamin A Supplementation and Vitamin A Status Are Associated with Gut Microbiome Composition in Bangladeshi Infants in Early Infancy and at 2 Years of Age.
译名：在孟加拉国，婴儿在早期和两岁时补充维生素A，维生素A的状态与肠道菌群组成紧密相关。
作者：Huda MN
期刊：J Nutr
发表日期：.6.1
IF：4.1450
PMID：31006815
译 文
背景：
婴儿阶段是建立肠道微生物群的关键时期。这一过程可能受到维生素A 状态的影响，因为VA影响肠道免疫和上皮完整性，而这些因素反过来又能调节微生物群的发育。
目的：
本研究的目的是确定在（6-15周）或2年内的婴儿阶段，新生儿补充VA（VAS）是否影响早期肠道双歧杆菌、有益的共生菌或变形杆菌（含肠道致病菌门）的丰度。次要目的是确定VAS是否影响其他细菌类群的丰度，并确定通过测量血浆视黄醇评估的VA状态是否与细菌丰度相关。根据性别和出生体重状况（高于/低于中位数），对306名孟加拉国婴儿进行随机分组，让他们在出生48小时内接受1 VA剂量（50,000 IU）或安慰剂治疗。通过16S rRNA基因测序，对属级及以上相对丰度进行评价。采用末端限制片段长度多态性方法对双歧杆菌和亚种进行了6周的鉴定。
结果：
线性回归分析结果表明，相较女性婴儿，男性婴儿早期的双歧杆菌的丰度偏低，但是接受VAS治疗的男婴高于安慰剂组的男婴。然而这种差异并未在女婴上看到，添加VA并未影响变形门菌的丰度。VA状态也与性别相关，在婴儿期晚期的女婴，其血浆视黄醇与放线菌（含双歧杆菌门）和Akkermansia（另一种可能有益于健康的共生菌）呈正相关关系。
结论：
婴儿期VA状态的改善，可能通过促进健康微生物群的建立而影响婴儿期和以后的健康。这种VA的假设效应在男孩和女孩之间可能有所不同。
原 文
BACKGROUND
Infancy is a crucial period for establishing the intestinal microbiome. This process may be influenced by vitamin A (VA) status because VA affects intestinal immunity and epithelial integrity, factors that can, in turn, modulate microbiome development.
OBJECTIVES
The aim of this study was to determine if neonatal VA supplementation (VAS) affected the abundance of Bifidobacterium, a beneficial commensal, or of Proteobacteria, a phylum containing enteric pathogens, in early (6-15 wk) or late (2 y) infancy. Secondary objectives were to determine if VAS affected the abundance of other bacterial taxa, and to determine if VA status assessed by measuring plasma retinol was associated with bacterial abundance.
METHODS
Three hundred and six Bangladeshi infants were randomized by sex and birthweight status (above/below median) to receive 1 VA dose (50,000 IU) or placebo within 48 h of birth. Relative abundance at the genus level and above was assessed by 16S rRNA gene sequencing. A terminal restriction fragment-length polymorphism assay was used to identify Bifidobacterium species and subspecies at 6 wk.
RESULTS
Linear regression showed that Bifidobacterium abundance in early infancy was lower in boys (median, 1st/3rd quartiles; 0.67, 0.52/0.78) than girls (0.73, 0.60/0.80; P=0.003) but that boys receiving VAS (0.69, 0.55/0.78) had higher abundance than boys receiving placebo (0.65, 0.44/0.77; P=0.039). However this difference was not seen in girls (VAS 0.71, 0.54/0.80; placebo 0.75, 0.63/0.81; P=0.25). VAS did not affect Proteobacteria abundance. Sex-specific associations were also seen for VA status, including positive associations of plasma retinol with Actinobacteria (the phylum containing Bifidobacterium) and Akkermansia, another commensal with possible health benefits, for girls in late infancy.
CONCLUSIONS
Better VA status in infancy may influence health both in infancy and later in life by promoting the establishment of a healthy microbiota. This postulated effect of VA may differ between boys and girls.
部分图文源于网络，如有侵权，立即删除。
▼往期精彩回顾▼研究：维生素D水平与特定种族的心脏代谢特征有关最新研究：维生素A摄入量与皮肤鳞状细胞癌风险的关系维生素E对受到力竭运动小鼠的影响
